Description
FOXO4-DRI Research Peptide
FOXO4-DRI is a synthetic D-retro-inverso peptide supplied for controlled laboratory investigation. It is extensively studied for its specific interaction within the FOXO4-p53 pathway, a critical area in cellular senescence research. Researchers examine this compound to understand its role in modulating senescent cell behavior and its potential implications for senolytic strategies. Its defined structure allows for consistent and repeatable studies under standardized conditions.
Because of its precise targeting of the FOXO4-p53 interaction, researchers value FOXO4-DRI for its utility in dissecting complex cellular processes related to aging and cellular dysfunction. Studies utilizing this compound contribute to understanding specific signaling patterns and interaction behaviors critical for maintaining cellular homeostasis. Its application in controlled environments allows for rigorous data consistency, essential for advanced senolytic research.
In laboratory settings, FOXO4-DRI is handled following standard peptide preparation and safety procedures. This compound is supplied as a lyophilized powder, suitable for reconstitution. For optimal stability, store the lyophilized powder in cool, dry conditions. After reconstitution, it is recommended to refrigerate at 2-8°C, and for extended storage, freeze at -20°C. Reconstitution with bacteriostatic water is typically performed.
The consistent composition of FOXO4-DRI ensures reduced variation across experimental trials, providing reliable data for long-term laboratory projects. Its suitability for structured research workflows supports investigations into complex biological systems, offering a dependable tool for researchers aiming for precise and reproducible results in senescent cell studies.
Ongoing research frequently includes FOXO4-DRI due to its defined sequence and stable behavior. This makes it highly suitable for controlled research models exploring cellular senescence and its modulation.
Important Notice: FOXO4-DRI 10mg is provided strictly for research use only. This product is not intended for human or animal use, clinical applications, diagnostic procedures, or consumption of any kind. All research must be conducted by qualified professionals in appropriate laboratory environments and in compliance with applicable regulations and guidelines.
Frequently Asked Questions
What is FOXO4-DRI?
FOXO4-DRI (D-retro-inverso) is a synthetic peptide, identified by CAS 2062663-67-0. It is designed as a D-retro-inverso sequence, a structural modification known to enhance peptide stability and resistance to enzymatic degradation in research models. This compound specifically targets the interaction between FOXO4 and p53, key proteins involved in cellular senescence pathways.
How does the D-retro-inverso modification affect FOXO4-DRI’s research utility?
The D-retro-inverso modification in FOXO4-DRI alters the peptide backbone while maintaining the spatial arrangement of side chains. In research, this structural change is studied for its potential to improve proteolytic stability and bioavailability within experimental systems compared to L-amino acid peptides. This can lead to more consistent and prolonged effects in vitro and in vivo research models, facilitating long-term studies.
What biological systems are studied using FOXO4-DRI?
FOXO4-DRI is primarily utilized in research focused on cellular senescence, a state of irreversible cell cycle arrest. Studies often involve examining its effects on senescent cell populations in various tissue and cell culture models. Researchers investigate its impact on the FOXO4-p53 signaling axis within these systems, exploring its role in the mechanisms underlying aging and age-related cellular dysfunction.
What is the proposed mechanism of action for FOXO4-DRI in research models?
In research models, FOXO4-DRI is studied for its ability to disrupt the interaction between the transcription factor FOXO4 and the tumor suppressor protein p53. This disruption is hypothesized to selectively induce apoptosis in senescent cells by preventing FOXO4 from sequestering p53 in the nucleus, thereby allowing p53 to activate pro-apoptotic pathways. This mechanism is central to its investigation in senolytic research.
Why is FOXO4-DRI of interest in senolytic research?
FOXO4-DRI is of interest in senolytic research because of its specific targeting of the FOXO4-p53 interaction, which is implicated in the survival of senescent cells. Researchers study its potential to selectively clear senescent cells from tissues, a process thought to mitigate age-related pathologies in experimental models. Its focused mechanism makes it a valuable tool for understanding and developing strategies for senescent cell modulation.
What are the recommended storage conditions for FOXO4-DRI?
For optimal stability, FOXO4-DRI as a lyophilized powder should be stored in a cool, dry place, typically at -20°C or colder. After reconstitution with an appropriate solvent like bacteriostatic water, the solution should be refrigerated at 2-8°C for short-term use. For extended storage of reconstituted solutions, aliquoting and freezing at -20°C or colder is recommended to maintain compound integrity.
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